What is Protonix?

Protonix is a proton pump inhibitor. The active ingredient in Protonix is pantoprazole which is dispensed as delayed-release tablets and a delayed-release oral suspension.

Drug Uses

Protonix is used to treat acid reflux related conditions that include heartburn, GERD (gastroesophageal reflux disease), Zollinger-Ellison syndrome, stomach ulcers and erosive esophagitis. The active ingredient in Protonix reduces the amount of acid produced by the stomach.

Protonix is used to treat other medical conditions not listed in this information guide.


Protonix must always be used as directed. Do not make adjustments to the dose before speaking to a doctor. Protonix can be taken with, or without, food.

The delayed-release capsules must never be chewed, broken or crushed. The capsule must be swallowed whole to ensure that the delayed-release mechanism works correctly.

Continue your treatment with Protonix as prescribed. Do not stop taking this medication even if there is an improvement in your condition. If you stop taking Protonix too soon, there is a risk of a recurrence of the infection. If, after using Protonix for eight weeks, there is no improvement in your condition, contact your doctor.

If using the oral suspension of Protonix shake the bottle well before use. Use a proper medical measuring device to ensure that the correct dose is administered.

Missed Dose

If you miss a dose, it may be taken when you remember. However, do not take the missed dose near the time of the next scheduled dose. In this case, ignore the missed dose. Never double-up on a dose.

Warnings and Precautions

Do not use Protonix if you are allergic to pantoprazole.

Long-term use of Protonix may result in the body being unable to absorb adequate amounts of vitamin B-12. Symptoms vitamin B-12 deficiency include fatigue, fast heart rate, pale skin, and weakness. If these symptoms occur, consult your doctor.

Before using Protonix, you must give your doctor full details of your medical history and other medications that you use. These include herbal medicines and vitamin supplements. Protonix can react badly with some medications.

Protonix is not likely to harm an unborn fetus so pregnant women are able to use this medication. It is not known if Protonix is passed into breast milk so women who are breast-feeding should use Protonix with caution, under directions of a doctor.

While using Protonix, your doctor may wish to restrict certain foods or drink in your diet.

Possible Side-effects

Call for emergency assistance if any of the following symptoms of allergy occur: difficulty in breathing, hives, or swelling of the lips, tongue, throat or face.

Less serious side-effects can include vomiting or nausea, diarrhea, stomach pain, or headache. These side-effects generally occur in the initial stages of treatment and do not last long.

Contact your doctor if any uncomfortable symptoms occur, or persist.


Overdose with Protonix is unlikely. However, excessive doses can cause serious symptoms. If overdose is suspected, call for emergency help immediately.

Storage instructions

Protonix must be kept away from children and stored in a dry, cool place away from sunlight and moisture.